Clinical characteristics of 254 cases of polypoidal choroidal vasculopathy

( views:1325, downloads:0 )
TAO Yong(Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100044, China)
HOU Jing(Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100044, China)
LI Xiao-xin(Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing 100044, China)
Journal Title:
Chinese Journal of Ocular Fundus Diseases
Volume 28, Issue 05, 2012
Key Word:
Choroid diseases; Macular degeneration; Disease attributes

Abstract: Objective To observe the clinical characteristics of polypoidal choroidal vasculopathy (PCV).Methods Two hundreds fifty-four PCV patients (306 eyes) were enrolled in this study.All the patients were examined for corrected visual acuity (BCVA) testing,slit-lamp microscope,indirect ophthalmoscopy,fundus photography,fluorescein angiography,indocyanine green angiography and optic coherence tomography.Results The patients included 152 males (59.8%) and 102 females (40.2%) ; the age was from 38 to 91 years,with a mean age of (65.4±8.9) years.Bilateral lesions were observed in 52 patients (20.5%) and unilateral lesions were observed in 202 patients (79.5%).BCVA varied from nonlight perception to 1.2.BCVA was lower than <0.1 in 167 eyes (54.6%),≥0.1 but <0.3 in 92 eyes(30.1%) and ≥0.3 in 47 eyes (15.4%).Vitreous hemorrhage was observed in 61 eyes (19.9%).In 202 patients with unilateral PCV lesions,drusen can be observed in the contralateral eyes of 68 patients (33.7%),exudative age-related macular degeneration changes in the contralateral eyes of 24 patients (11.9 %),and central serous chorioretinopathy history was positive in the contralateral eyes in nine patients (4.5%).In 306 eyes,there were 43 eyes (14.1%) with high permeable choroid.PCV lesions located at macula area in 199 eyes (65.0%),under the temporal retinal vascular arcade in 49 eyes (16.0%),and peripapillary in 15 eyes (4.9%).PCV lesion formation was single in 110 eyes (35.9%),cluster in 176 eyes (57.5%),string in three eyes (1.0%),branch in four eyes (1.3%),and both single and cluster polyps in 13 eyes (4.2%).There were 125 eyes (40.8%) with sub-neuroretinal fluid,121 eyes (39.5%) with hemorrhagic pigment epithelium detachment,and 73 eyes (22.9%) with serous pigment epithelium detachment.Conclusion PCV patients have higher bilateral incidence and female prevalence,and lower rate of peripapillary lesions.

  • [1]Stern RM,Zakov ZN,Zegarra H,et al.Multiple recurrent serosanguineous retinal pigment epithelial detachments in black women.Am J Ophthalmol,1985,100:560-569.
  • [2]Yannuzzi LA,Sorenson J,Spaide RF,et al.Idiopathic polypoidal choroidal vasculopathy (IPCV).Retina,1990,10:18.
  • [3]Ciardella AP,Donsoff IM,Huang SJ,et al.Polypoidal choroidal vasculopathy.Surv Ophthalmol,2004,49:25-37.
  • [4]Kwok AK,Iai TY,Chan CW,et al.Polypoidal choroidal vasculopathy in Chinese patients.Br J Ophthalmol,2002,86:892 897.
  • [5]Lafaut BA,Leys AM,Snyers B,et al.Polypoidal choroidal vasculopathy in Caucasians.Graefe' s Arch Clin Exp Ophthalmol,2000,238:752-759.
  • [6]Yamaoka S,Okada AA,Sugahara M,et al.Clinical features of polypoidal choroidal vasculopathy and visual outcomes in the absence of classic choroidal neovascularization.Ophthalmologica,2009,224:147-152.
  • [7]Uyama M,Matsubara T,Fukushima I,et al.Idiopathic polypoidal choroidal vasculopathy in Japanese patients.Arch Ophthalmol,1999,117:1035-1042.
  • [8]Scassellati-Sforzolini B,Mariotti C,Bryan R,et al.Polypoidal choroidal vasculopathy in Italy.Retina,2001,21:121-125.
  • [9]Wen F,Chen C,Wu D,et al.Polypoidal choroidal vasculopathy in elderly Chinese patients.Graefe's Arch Clin Exp Ophthalmol,2004,242:625-629.
  • [10]Hwang DK,Yang CS,Iee FL,et al.Idiopathic polypoidal choroidal vasculopathy.J Chin Med Assoc,2007,70:84-88.
  • [11]Liu Y,Wen F,Huang S,et al.Subtype lesions of neovascular age-related macular degeneration in Chinese patients.Graefe' s Arch Clin Exp Cphthalmol,2007,245:1441-1445.
  • [12]文峰,吴德正,李海涛,等.息肉状脉络膜血管病变的眼底特征分析.中华眼底病杂志,2003,19:269-272.
  • [13]文峰,吴德正,李海涛.息肉状脉络膜血管病变的随访观察.中华眼底病杂志,2004,20:8-11.
  • [14]Japanese Study Group of Polypoidal Choroidal Vasculopathy.Criteria for diagnosis of polypoidal choroidal vasculopathy.Nihon Ganka Gakkai Zasshi,2005,109:417-427.
  • [15]文峰,吴德正,孙祖华,等.息肉状脉络膜血管病变的分类研究.眼科学报,2006,22:160-165.
  • [16]Spaide RF,Yannuzzi IA,Slakter JS,et al.Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy.Retina,1995,15:100-110.
  • [17]Yannuzzi LA,Ciardella A,Spaide RF,et al.The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy.Arch Ophtahlmol,1997,115:478-485.
  • [18]Yannuzzi LA,Wong DWK,Sforzolini BS,et al.Polypoidal choroidal vasculopathy and neovascular age related macular degeneration.ArchOphthalmol,1999,117:1503-1510.
  • [19]Ahuja RM,Stanga PE,Vingcrling JR,et al.Polypoidal choroidal vasculopathy in exudative and haemorrhagic pigment epithelium detachments.Br J Ophthalmol,2000,84:479-484.
  • [20]Ladas ID,Rouvas AA,Moschos MM,et al Polypoidal choroidal vasculopathy and exudative age related macular degeneration in Greek population.Eye (Lond),2004,18:455-459.
  • [21]Sho K,Takahashi K,Yamada H,et al.Polypoidal choroidal vasculopathy:incidence,demographic features,and clinical characteristics.Arch Ophthalmol,2003,121:1392-1396.
  • [22]Maruko I,Iida T,Saito M,et al.Clinical characteristics of cxudative age-related macular degeneration in Japanese patients.Am J Ophthalmol,2007,144:15-22.
  • [23]Hou J,Tao Y,Li XX,et al.Clinical characteristics of polypoidal choroidal vasculopathy in Chinese patients.Graefe's Arch Clin Exp Ophthalmol,2011,249:975-979.
  • [24]Imamura Y,Engelbert M,Iida T,et al.Polypoidal choroidal vasculopathy:a review.Surv Ophthalmol,2010,55:501-515.
  • [25]Yeung L,Chen SN.Polypoidal choroidal vasculopathy in Taiwan.Chang Gung Med J,2004,27:366-372.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615