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Investigation of concentration of vascular endothelial growth factor in plasma and intraocular liquid in diabetic retinopathy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1005-1015.2004.06.003
- Key Word:
- 内皮,血管;血管生长因子/分析;糖尿病性视网膜病变/血液;眼房水/化学
Abstract： 目的通过检测糖尿病性视网膜病变(DR)患者血浆、眼内液(房水、玻璃体)血管内皮生长因子(VEGF)含量,探讨其在DR发展变化中的作用.方法采用双抗体夹心酶联免疫吸附试验ELISA法定量检测患者组及对照组血浆、房水、玻璃体VEGF含量.结果无糖尿病性视网膜病变(NDR)组血浆VEGF含量(34.47±1.76)pg/ml,单纯型糖尿病性视网膜病变(BDR)组血浆VEGF含量(53.93±3.08)pg/ml,增生型糖尿病性视网膜病变(PDR)组血浆VEGF含量(53.36±3.28)pg/ml,对照组血浆VEGF含量(178.30±10.13)pg/ml,与实验组比较差异均有显著性的意义(P＜0.05)PDR组房水VEGF含量(184.86±12.60)pg/ml,对照组房水VEGF含量(90.06±18.32)pg/ml,两者比较差异有显著性的意义(P＜0.05);PDR组玻璃体VEGF含量(741.70±92.02)pg/ml,对照组玻璃体VEGF含量(94.38±21.21)pg/ml,两者比较差异有显著性的意义(P＜0.05).PDR组血浆VEGF与房水、玻璃体VEGF无相关关系(P＞0.05),玻璃体VEGF与糖化血红蛋白(HbA1c)有正相关关系(r=0.9067,P＜0.01).结论糖尿病患者血浆VEGF含量较正常人低,但与房水、玻璃体VEGF含量无关;增生型糖尿病性视网膜病变患者房水与玻璃体VEGF含量增高,玻璃体内VEGF含量增高与患者HbA1c值有关.
- [1]Baba T,Sato W,Watanabe T,etc.Plasma vascular endothelial growth factor in Japanese Type 2 diabetic patients with and without nephropathy.[J].2002,16(6).
- [2]J Pe'er,R Folberg,A Itin,etc.Upregulated expression of vascular endothelial growth factor in proliferative diabetic retinopathy.[J].1996,80(3).
- [3]Lutty Gerard A..Localization of Vascular Endothelial Growth Factor in Human Retina and Choroid[J].1996.