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Determine the polymorphisms and parent's gene-sharing rate of LMP2 in women with pre-eclampsia and the relationship with severe pre-eclampsia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1007-9408.2006.03.003
- Key Word:
- 先兆子癎;多功能蛋白酶;多态性,限制性片段长度
Abstract： 目的测定重度子癎前期(severe pre-eclampsia,S-PE)患者和正常孕妇多功能蛋白酶(1arge multifunctional protease,LMP2)基因多态性及夫妻共享率,探讨该基因与S-PE发病的相关性.方法选择102例S-PE患者及其配偶为研究对象,随机选择200例正常孕妇及其配偶作为对照.所选孕妇均为单胎初孕,孕35～40周.各取2 ml外周静脉血抽提DNA,应用PCR-RFLP方法进行LMP2基因分型. 结果 LMP2R/H在S-PE患者中的分布频率显著高于正常孕妇组(53.9%和35.5%,P＜0.01),LMP2R/R在S-PE患者中的分布频率显著低于正常孕妇组(41.2%和58.5%,P＜0.01).LMP2R/H在S-PE组的夫妻共享率与正常孕妇组的相比显著增高(24.5%和10.5%,P＜0.01). 结论 LMP2R/H很可能为S-PE发病的易感基因;而LMP2R/R可能是S-pE的保护基因.
- [1]高眉扬,傅静,吴爱华,等.妊高征患者封闭抗体对配偶T淋巴细胞分化抗原CD3、CD4、CD8的影响[J].2004,(6).
- [2]Cascio P,Goldberg AL,Saric T,etc.The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides.[J].2002,39(3).
- [3]丁鹤林,程桦,傅祖植.LMP2基因多态性与胰岛素依赖型糖尿病及DR3基因的关系[J].1999,(1).
- [4]吴乾渝,张振钧,毛羽,等.妊娠高血压综合征与HLA-DRB1关联研究[J].1997,(6).
- [5]Rehermann B,Sijts BA,Ruppert T,etc.Efficient generation of a hepatitis B virus cytotoxic T lymphocyte epitope requires the structural features of immunoproteasomes.[J].2000,191(3).
- [6]D C, Kilpatrick,W A, Liston,F, Gibson,etc.Association between susceptibility to pre-eclampsia within families and HLA DR4.[J].1989,2.
- [7]Murray RZ.,Mason GGF.,Brooks P.,etc.Association of immunoproteasomes with the endoplasmic reticulum[J].2000,352(Pt.3).
- [8]Deng GY,Muir A,Maclaren NK,etc.Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.[J].1995,56(2).
- [9]J M, Heward,A, Allahabadia,M C, Sheppard,etc.Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501.[J].1999,51(1).