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Effect on Cytokine Production of Placental Villi by Hypoxia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF PERINATAL MEDICINE
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1007-9408.2000.01.005
- Key Word:
- 胎盘;低氧;肿瘤坏死因子;转化生长因子β
Abstract： 目的 探讨缺氧对胎盘绒毛分泌肿瘤坏死因子-α(TNF-α)和转化生长因子-β1(TGF-β1)的影响.方法 7例正常足月胎盘绒毛分别在常氧和低氧(5%O2)条件下培养,采用ELISA方法测定胎盘绒毛培养液中TNF-α和TGF-β1水平.结果 低氧条件下培养1、4、12、24 h胎盘绒毛分泌TNF-α的量分别为(69.5±13.1、128.7±16.5、241.4±90.5、175.3±93.9)pg/克湿重,显著高于常氧条件下培养,分别为(52.4±10.7、99.3±16.1、147.9±20.3、116.4±21.2)pg/克湿重, 但分泌TGF-β1的水平二者无显著性差异.结论 胎盘缺氧能大量产生某种细胞因子,可能参与妊高征的病理发生过程.
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