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Interpretation points to NCCN 2008 clinical practice guidelines in oncology:hereditary nonpolyposis colorectal cancer screening
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF HEALTH MANAGEMENT
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1674-0815.2009.01.004
- Key Word:
- No keyword available
Abstract： @@ 遗传性非息肉病性结肠癌(hereditary nonpolyposis colon cancer,HNPCC),也称Lynch综合征,占结直肠癌发病总数的2%～3%[1].其发病机制主要是由于DNA错配修复基因(主要是MLH1,MSH2,MSH6,PMS2)突变导致,携带一个HNPCC突变基因的个体终生结直肠癌的危险度为80%[2].HNPCC的主要临床特点为肿瘤发病年龄早,通常在50岁前发生结肠癌,好发于近端结肠(盲肠、升结肠和横结肠),有同时或异时原发性结肠癌,且常见肠外恶性肿瘤,肠外恶性肿瘤最常见的部位是子宫内膜,其次是胃、小肠、肝胆系统、上泌尿道和卵巢等.HNPCC的主要危险是以常染色体显性遗传方式传给子代,尤其是一级或二级亲属好发结肠癌.HNPCC临床预后较好,早期发现、早期治疗将极大改善患者的预后.对HNPCC患者及其亲属必须进行密切的监测,NCCN指南[3]对HNPCC的筛查包括分子诊断、遗传检测、随访监测及手术治疗等.
- [1]Heikki J. Järvinen,Jukka-Pekka Mecklin,Pertti Sistonen.Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer[J].1995,108(5).
- [2]H F, Vasen.Clinical diagnosis and management of hereditary colorectal cancer syndromes.[J].2000,18(21 Suppl).
- [3]Henry T, Lynch,Albert, de la Chapelle.Hereditary colorectal cancer.[J].2003,348(10).