Abstract： Objective To explore the effect of simulated ship motion on the anesthetic sensitivity of propofol in patients,so as to provide cvidcncc for rational application of propofol during deployment at sea.Methods The motion sickness model was developed by using the rotating-chair test.Seventy-five cases of motion sickness were randomly divided into 5 groups,each consisting of 15.Of the 75 cases,60 were divided into the non-rotation and rotation groups.Then,each group was treated with a single injection of propofol and a single injection + continuous infusion of propofol.Thereby,2 anesthesia groups ( with anesthesia only,but no rotation) and 2 experimental groups (with rotation first,then anesthesia) were formed.In addition,a control group (with rotation only,but without anesthesia) was established.The determination of anesthetic sensitivity consisted of 2 parts:( 1 ) Dynamic changes in the vital signs and entropy indexes for the anesthesia and experimental groups were detected following injection of a single dose of propofol with the same dosage,and a comparison was made between them.(2)Hemodynamics and state entropy (SE) were maintained within 55％ -60％,and then,infusion rate and serum concentration of propofol were compared between the anesthesia group and the experimental group.Results Following a single injection of propofol,SE and RE (response entropy) for the experimental group were all obviously lower than those of the anesthesia group.The time for the experimental group and the anesthesia group to reach the minimal SE value were (51.00 ± 12.36)s and (67.50 ± 14.72)s respectively,with that of the experimental group obviously being shorter,and statistical significance could be noted,when a comparison was made between the two (P ＜ 0.01 ).For the experimental group,continuous infusion of propofol to maintain SE within 55％-60％ for 30 min,an infusion rate of (3.36 ± 0.98) mg/( kg · h) and a serum propofol concentration of (2.95 ± 0.79 ) μg/ml were required.For the anesthesia group to reached the same state,an infusion rate of (5.38 ±0.84) mg/(kg · h ) and a serum propofol concentration of (4.41 ± 0.87) μg/ml were required respectively,with those of the experimental group obviously shorter,and statistical significance could be observed,when a comparison was made between the two (P ＜ 0.01 ).The minimal infusion rates required by the experimental group and the anesthesia group were 2.00 mg/( kg · h) and 5.00 mg/( kg · h) respectively,with that of the experimental group obviously lower,and statistical significance could be observed,when a comparison was made between the two ( P ＜0.01 ).在 Patients in the control group displayed a prolonged dizziness and a shorter duration of somnolence.Ramsay’s sedative score decreased,with SE and RE respectively decreased to 66％ and 52％.Conclusions Simulated ship motion could obviously help patients to tolerate propofol.Cerebral cortex inhibition induced by rotation might be one of the mechanisms involved.