Abstract： Objective To investigate therapeutic effect of Edaravone combined with HBO on acute cerebral infarction in 83 cases. Methods One hundred and sixty - six cases of acute cerebral infarction were equally divided into two groups, the Edaravone treatment group (the simple medication group) (n = 83) and the Edaravone combined with HBO treatment group (the medication plus HBO group) (n = 83). The simple medication group was administered with an injection of 30 mg Edaravone twice a day, and the medication plus HBO group was treated by Edaravone combined with HBO. Neural function was compared and analyzed between the groups following 3 weeks of treatment to assess therapeutic effects, to monitor prothrombin time (PT), and the level of fibronogen. Results After the second and third week of the treatment, neural functional scores and therapeutic efficacy for the medication plus HBO group were obviously better than those of the simple medication group (P < 0. 05 or 0. 01). The level of PT for the medication plus HBO group was obviously greater (P <0. 05), while the level of serum FIB was significantly lower than that of the simple medication group (P < 0. 05 or 0. 01). Conclusions The therapeutic effect of Edaravone combined with HBO was obviously better than that of the simple medication group. In addition, Edaravone combined with HBO could obviously increase the levels of PT and decrease the levels of FIB.