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Effects of 0.7 MPa hyperbaric pressure on the release or uptake of γ-aminobutyric acid by rat brain synaptosomes, nerve cells and glial cells
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1009-6906.2007.02.001
- Key Word:
- 高气压;γ-氨基丁酸;突触体;神经细胞;神经胶质细胞
Abstract： 目的 研究0.7MPa(7 ATA)氮氧混合气对大鼠纹状体、下丘脑、中脑和小脑突触体以及神经元和神经胶质细胞释放及摄取γ-氨基丁酸(GABA)的作用.方法 同位素液体闪烁检测技术检测突触体和细胞释放标记GABA的量和摄取标记GABA的量.结果 纹状体、下丘脑和中脑突触体释放GABA增加,小脑释放GABA无明显变化.纹状体、下丘脑、中脑和小脑突触体摄取GABA均增加.SK-N-SH细胞释放和摄取GABA明显增加.C6细胞摄取GABA增加.结论 0.7 MPa氮氧混合气条件下GABA神经递质代谢加快,其抑制功能可能减弱.
- [1]Zoli M,Agnati LF.Wiring and volume transmission in the central nervous system: the concept of closed and open synapses.[J].1996,49(4).
- [2]Piet, R.,Poulain, D. A.,Oliet, S. H..Modulation of synaptic transmission by astrocytes in the rat supraoptic nucleus[J].2002,96(3).
- [3]吴馥梅,杨丽娅,萧信生.突触体研究简介[J].1995,(2).
- [4]关永家主编.高气压医学[M].1992.
- [5]B.G. Zhu,D.H. Zhu,Y.Z. Chen.Rapid Enhancement of High Affinity Glutamate Uptake by Glucocorticoids in Rat Cerebral Cortex Synaptosomes and Human Neuroblastoma Clone SK-N-SH: Possible Involvement of G-protein[J].1998,247(2).
- [6]韩济生,1928-.神经科学原理[M].1900.