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The relationships of angiotensin-converting enzyme gene polymorphism with plasma lipids and fibrinogen
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NAUTICAL MEDICINE AND HYPERBARIC MEDICINE
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1009-6906.2002.04.003
- Key Word:
- 血管紧张素转换酶;基因;血脂;纤维蛋白原
Abstract： 目的研究血管紧张素转换酶(ACE)基因多态性与血脂及血浆纤维蛋白原(Fg)之间的相关关系.方法对126例冠心病、高血压病患者和66例健康对照者分别进行ACE基因多态性和血脂(包括CH、TG、HDL-c、LDL-c)、Fg浓度测定,分析ACE基因多态性与血脂及Fg之间的关系.结果(1)疾病组DD基因型频率和D等位基因频率较正常对照组明显增高(P＜0.01);(2)疾病组CH、TG、LDL-c、Fg水平明显高于对照组(P＜0.05),而HDL-c水平明显低于对照组(P＜0.05).且疾病组中ACE基因DD型者与ID、Ⅱ型者间相比差异有显著性(P＜0.05);(3)ACE基因多态性与CH、TG、LDL-c及Fg浓度间呈显著正相关(r值分别为0.671,0.702,0.683,0.653,P值均＜0.01);与HDL-c浓度间存在显著负相关(r=-0.648,P＜0.001).结论ACE基因DD型和D等位基因与血脂代谢异常及血浆Fg有关,而与Ⅰ等位基因无关.
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