Abstract： Objective To observe the influence of jinshuibao capsule on serum cystatin C and high sensitive C-reactive (hs-CRP)protein in chronic kidney disease patients (CKD). Methods Thirty-four cases CKD patients were randomly divided into two groups: control group (17 cases) and treatment group (treatment with jinshuibao capsules, 17 cases). Meanwhile, 17 healthy adults were taken as the normal control. The blood concentrations of cystatin C, hs-CRP, Scr and BUN were determined. Results The level of cystatin C, hs-CRP,Scr in all CKD patients were significantly higher than those in the normal control(P＜ 0. 05), the level of cystatin C, hs-CRP, Scr decreased after 8 weeks of conventional treatment (P ＞ 0.05) , while those significantly decreased addition of jinshuibao capsule treatment(P ＜0. 05); Cystatin C and hs-CRP were positively correlated,but Cystatin C was negatively correlated with GFR. Conclusion The renal function and inflammation can be alleviated by jinshuibao capsule in early CKD patients, which could be slowed the progression of CKD.