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The concept of tumor-derived exosomes and research progress in bone metastasis of prostate cancer
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- Author:
- No author available
- Journal Title:
- National Medical Journal of China
- Issue:
- 42
- DOI:
- 10.3760/cma.j.issn.0376-2491.2019.42.003
- Key Word:
- 肿瘤源性外泌体;前列腺癌;骨转移;上皮-间质转化;血管生成
Abstract： 外泌体作为一种小囊泡结构负责细胞间通讯工作,几乎可由所有细胞分泌.转移性前列腺癌90％以上部位为骨转移,前列腺癌这种特殊的"亲骨性"涉及到前列腺癌细胞与细胞外基质、血管内皮和骨髓微环境之间的细胞间信号通讯等复杂过程.本文就肿瘤源性外泌体(TDE)作为细胞间通讯工具诱导上皮-间质转化、血管通透性改变及血管生成、转移前微环境形成等以促使前列腺癌骨转移的发生进行了论述.
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