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亚洲人群静脉血栓栓塞症相关基因多态性研究进展

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Author:: No author available

Journal Title:: National Medical Journal of China

Issue:: 18

DOI:: 10.3760/cma.j.issn.0376-2491.2019.18.018

Key Word:: 静脉血栓形成;基因

Abstract：静脉血栓栓塞症(VTE)是由遗传、环境、行为等多种因素共同作用的疾病,VTE的发生50％～60％可归因于遗传因素.现已知的遗传因素在东西方人群中存在较大差异,蛋白C缺陷、蛋白S缺陷以及抗凝血酶缺陷是亚洲人群主要的遗传缺陷类型.PAI-1、MTHFR、TAFI等基因多态性与亚洲人群VTE发生风险之间的关系受到了越来越多的重视.本文就亚洲人群VTE相关基因多态性的研究进展及与其他种族人群的差异进行了综述.

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