Personalized repeat Gamma Knife Radiosurgery treatment in patients with recurrent refractory trigeminal neuralgia
- Author:
- No author available
- Journal Title:
- National Medical Journal of China
- Issue:
- 25
- DOI:
- 10.3760/cma.j.issn.0376-2491.2018.25.009
- Key Word:
- 复发性药物难治性三叉神经痛;二次伽玛刀治疗;远期预后;不良反应;Recurrent refractory trigeminal neuralgia;Repeat gamma knife radiosurgery treatment;Long-term prognosis;Untoward effect
Abstract： Objective To analyze the prognosis and untoward effect in recurrent refractory trigeminal neuralgia(RRTN)patients who underwent repeat Gamma Knife Radiosurgery treatment(GKRS)retrospectively,and to summarize the experience of repeat Gamma Knife Radiosurgery treatment of recurrent refractory trigeminal neuralgia.Methods RRTN patients who treated with repeat GKRS during 1998.8.1 to 2014.10.1 in Gamma Knife treatment Center of the Fifth Affiliated Hospital of Zhengzhou University were involved.The factors influencing long-term prognosis and facial numbness adverse reactions were statistically analyzed.Results Therapeutic dose was an independent factor that influence long-term prognosis of RRTN patients.Therapeutic dose was a dangerous factor that influence long-term facial numbness.Interval time between twice GKRS treatment was a favorable factor for facial numbness.Long-term prognosis of repeat GKRS treatment was positively correlated with therapeutic dose.Untoward effect of facial numbness after repeat GKRS treatment was positively correlated with therapeutic dose and negatively correlated with interval time between twice GKRS treatment.Conclusions Repeat GKRS for RRTN patients is safe and effective,but personalized treatment plan should be given according to the patient ′s own condition.
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