Abstract： Objective To evaluate the efficacy of endotracheal tube for drug injection in postoperative ICU patients.Methods A total of 60 ICU patients who were given mechanical ventilation after surgical treatment were enrolled in this study from January 2015 to August 2016 at our hospital.All the patients were divided into the observation group (30 cases) and the control group (30 cases).In the observation group,the patients were treated with the endotracheal tube for surface anesthesia by injecting 2% lidocaine into the trachea,and patients in the control group were treated with saline instead of lidocaine.Patients' tolerance to endotracheal tube,cardiovascular system adverse reactions,the frequency and dosage of sedative and analgesic drug within 12 h mechanical ventilation post operation were analyzed and compared between the two groups.Results The occurrence rate of cough,hypertension and tachycardia in the observation group were(0.6±0.3),(0.8±0.3)and(1.3±0.6),respectively,which were significantly lower than the control group (5.9±2.1),(6.0±1.9)and(4.9±1.8),the differences were statistically significant (P<0.05).In addition,the frequency of sedative drug was (0.8±0.3),with a dosage of midazolam(1.2±0.3)mg.While in the control group,the frequency of sedative drugs was (5.1±1.9),with a dosage of midazolam (9.9±3.2) mg.The frequency and dosage of sedative drug administration in the observation group were significantly lower than those in the control group,the difference was significant difference (P<0.05).Conclusions The use of endotracheal tube for drug injection can improve the tolerance of ICU patients to endotracheal tube,reduce the dosage of sedative drugs,and reduce the adverse cardiovascular reactions.