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内源性雄激素调节的新靶点和新进展
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- Author:
- No author available
- Journal Title:
- National Medical Journal of China
- Issue:
- 36
- DOI:
- 10.3760/cma.j.issn.0376-2491.2016.36.023
- Key Word:
- No keyword available
Abstract： 睾酮是一种类固醇激素,相对分子质量为288,由睾丸间质细胞合成与分泌,体内少部分雄激素来源于肾上腺.睾酮是男性体内分泌量最多、生理作用最重要的雄激素,其贯穿从胚胎发育到衰老的全部男性生理活动中,对男性生活质量有重大影响[1].因此,全面了解睾酮生物合成及调节途径对治疗男性雄激素缺乏具有重要的意义.95％的睾酮是由睾丸间质细胞合成和分泌的,睾酮主要由经典的下丘脑-垂体-性腺轴途径来调控.下丘脑分泌促性腺激素释放激素,分为促卵泡激素释放激素和促黄体激素释放激素,两者作用于脑垂体使之分泌促性腺激素,分为卵泡刺激素和黄体生成素(LH),后者作用于睾丸间质细胞膜上的LH受体,使睾丸间质细胞分泌睾酮.同时,睾酮对下丘脑和垂体具有负反馈调节作用[2].近年来,越来越多的科学家在研究LH是如何影响睾丸间质细胞的分泌和调控,为此,本文就雄激素调节的新靶点作一综述.
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