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骨骼肌萎缩中的自噬现象及在慢性肾脏病中的研究前景

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Author:: No author available

Journal Title:: National Medical Journal of China

Issue:: 22

DOI:: 10.3760/cma.j.issn.0376-2491.2013.22.020

Key Word:: No keyword available

Abstract：慢性肾脏病患者营养不良相当常见.肾性营养不良称为"蛋白质-能量消耗"(protein-energy wasting,PEW),主要表现为骨骼肌萎缩,此与患者预后密切相关,可增加其病死率.阐明骨骼肌萎缩的机制,并以此作为治疗靶点,可改善患者生存质量.目前认为,骨骼肌萎缩主要由几个蛋白降解途径增强引起蛋白质降解超过蛋白合成所致,其中最重要的蛋白降解途径是泛素-蛋白酶体途径(UPS).然而,近期研究表明,其他蛋白降解系统含半胱氨酸的天冬氨酸蛋白水解酶、钙蛋白酶及自噬-溶酶体系统(autophagy-lysosomal pathway,ALP)同样参与了骨骼肌萎缩的发生[1].

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