Abstract： Objective To explore the blood oxygen saturation and heart rate changes of the Antarctic expeditioners.Methods During August 2010 to April 2011,the changes in blood oxygen saturation,heart rate and plateau reaction of 16 Antarctic expedition team in different plateau environments (Tibetan plateau versus Antarctic plateau) were monitored with the noninvasive pulse oximeter MD300-C.The extent of acute mountain sickness was determined according to the Lake Louise Consensus acute mountain reaction symptom scores and judgment method.Results The changes of blood oxygen saturation,heart rate at different altitudes of 110,3650,4300 m (96.8％ ± 1.2％,89.1％ ± 1.2％,86.1％ ±2.0％,(75.0 ± 5.4) times/min,(104.0 ± 4.3) times/min,(113.0 ± 5.2) times/min,F =214.155,240.088,both P ＜0.05).With rising latitude and elevation gradient in Antarctic plateau,the changes of blood oxygen saturation,heart rate at different altitudes of 2000,2500,3000,3500 and 4087 m(91.9％ ± 1.3％,90.5％ ±1.3％,87.6％ ±1.4％,85.0％ ±1.8％,81.5％ ±2.2％,(85.9 ±3.2) times/min,(90.6 ±2.8) times/min,(97.8 ± 4.1) times/min,(102.0 ± 3.4) times/min,(106.3 ± 3.9) times/min,F =105.418,90.174,both P ＜ 0.05).Levels of blood oxygen saturation and heart rate were both correlated with the risk of altitude sickness(r =-0.446 and 0.565,both P ＜ 0.05).Conclusions As the increases of altitude,there are significant changes in oxygen saturation,heart rate of the Antarctic expeditioners.And with the increases of altitude,the risk of altitude sickness gradually increases.