Abstract： Objective To explore the feasibility and efficiency of new clamping technique of renal arterial branches during laparoscopic partial nephrectomy.Methods Between March and June 2011,10patients (6 males,4 females) with small renal tumor underwent laparoscopic partial nephrectomy with highly selective clamping of renal arterial branches.The mean age was (47 ± 13 ) years and the mean tumor size (2.8 ± 0.9 ) cm.Operative duration,estimated blood loss,time for highly selective clamping of renal arterial branches,postoperative hospital stay,indwelling duration of drainage tube and complications were recorded.Results The operations were successfully performed in all patients.The mean operative duration was (101 ±23) min,the mean estimated blood loss 112 ml and the mean time for the clamping of renal arterial branches (28 ± 6) min.There was neither blood transfusion nor conversion into open surgery.The mean indwelling duration of drainage tube was (5.0 ± 1.3 )days and the mean postoperative hospital stay (8.0 ±0.8)days.The recovery of all patients was uneventful.Conclusion Highly selective clamping of renal arterial branches is a new method of protecting renal function during laparoscopic partial nephrectomy.Further studies and a longer follow-up are warranted.