Paper - WANFANG MED ONLINE

You Position: Home > Paper

CTLA-4基因多态性与哮喘遗传易感性研究进展

( views:578, downloads:180 )

Author:: No author available

Journal Title:: National Medical Journal of China

Issue:: 6

DOI:: 10.3760/cma.j.issn.0376-2491.2012.06.019

Key Word:: No keyword available

Abstract：哮喘是以树突状细胞介导的Ⅱ型辅助性T细胞(Th2细胞)优势免疫为特征的慢性气道炎症性疾病[1],与多基因遗传有关,同时受遗传因素和环境因素的双重影响.患者个体特应质及环境因素的影响是发病的危险因素.细胞毒性T淋巴细胞相关抗原4( cytotoxic T-lymphocyte antigen-4,CTLA -4)是活化T细胞表面所表达的一种膜融合蛋白[2-3],可与CD28竞争结合抗原递呈细胞(APC)表面的B7分子,能够抑制T细胞活化、增殖,诱导T细胞免疫耐受,在抗过敏、抗肿瘤、抗移植排斥反应、抗自身免疫性疾病和变态反应性疾病中起重要作用.现就CTLA-4基因多态性与哮喘遗传易感性的关系综述如下.

Reference

[1]周林福,胡志斌,谢维,等.Toll样受体4基因多态性和内毒素在哮喘发病中的交互作用[J].2010,(2).
[2]Lombardi V,Singh AK,Akbari O.The role of costimulatory molecules in allergic disease and asthma.[J].2010,151(3).
[3]Kyu-Young, Oh,Mi-Jin, Kang,Won-Ah, Choi,etc.Association Between Serum IgE Levels and the CTLA4 +49A/G and FCER1B -654C/T Polymorphisms in Korean Children With Asthma.[J].2010,2(2).
[4].Pretibial myxedema is associated with polymorphism in exon 1 of CTLA-4 gene in patients with Graves' ophthalmopathy.[J].2009,301(10).
[5]Sharad, Purohit,Robert, Podolsky,Christin, Collins,etc.Lack of correlation between the levels of soluble cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) and the CT-60 genotypes.[J].2005,2.
[6]Ghaderi A,Saberi-Firozi M,Fattahi MJ,etc.CTLA-4 gene promoter and exon 1 polymorphisms in Iranian patients with gastric and colorectal cancers.[J].2007,22(12).
[7]Undlien DE.CTLA-4 polymorphisms in allergy and asthma and the TH1/TH2 paradigm.[J].2004,114(2).
[8]Fernandez Mestre M,Sanchez K,Balbas O.Influence of CTLA-4 gene polymorphism in autoimmune and infectious diseases.[J].2009,70(7).
[9]Douroudis K,Heinonen M,Laine AP.Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.[J].2009,70(7).
[10]Liu J,Shen H,Hu L,etc.CTLA-4 gene polymorphism +49 A/G contributes to genetic susceptibility to two infection-related cancers-hepatocellular carcinoma and cervical cancer.[J].2010,71(9).
[11]Bleecker ER.Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28.[J].2002,110(5).
[12]Hironori, Ueda,Joanna M M, Howson,Laura, Esposito,etc.Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.[J].2003,423(6939).
[13]Esteghamati A,Khalilzadeh O,Mobarra Z.Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients.[J].2009,20(4).
[14]Matt, Tector,Bhupendra O, Khatri,Karen, Kozinski,etc.Biochemical analysis of CTLA-4 immunoreactive material from human blood.[J].2009,10.
[15]Anderson, G,Gabrysovaa, L,Minaee, S,etc.Enhanced selection of FoxP3(+) T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease[J].2009,106(9).
[16]Alison Taylor,Christopher E. Rudd,Helga Schneider.CD28 and CTLA-4 coreceptor expression and signal transduction[J].2009,229.
[17]Kim SH,Kim KE,Park HS,etc.Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children.[J].2007,42(6).
[18]Bicek A,Zaletel K,Gaberscek S.49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease.[J].2009,70(10).
[19]Wong AK,Vyse TJ,Whittaker JC,etc.Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study.[J].2006,15(21).
[20]Jasek, M.,Luszczek, W.,Obojski, A.,etc.Distribution of CTLA-4 Polymorphisms in Allergic Asthma[J].2006,141(3).