Role of papillomavirus in adenocarcinoma of esophagogastric junction
- Author:
- No author available
- Journal Title:
- NATIONAL MEDICAL JOURNAL OF CHINA
- Issue:
- 32
- DOI:
- 10.3760/cma.j.issn.0376-2491.2010.32.007
- Key Word:
- 食管胃接合处;腺癌;人乳头瘤病毒属;Esophagogastric junction;Adenocarcinoma;Lambdapillomavirus
Abstract： Objective To determine if human paillomavirus (HPV) infection could be associated with the development of adenocarcinoma of esophagogastric junction (AEG). Methods A total of 106 consecutive AEG patients and 59 consecutive gastric carcinoma patients who accepted surgery at our department between January 2004 and December 2006 were selected. Specimens from tumors and uninvolved mucosa were obtained intra-operatively. Genomic DNA was extracted by the phenol-chloroform-isoamyl alcohol extraction protocol. The HPV infection was determined by PCR using primer set SPF1 and GP6 +.Specificity of the amplified products was confirmed by sequencing. Results The HPV infection rates in AEG and gastric cancer were 10.4% (11/106) and 10.2% (6/59) separately (P=0.966). Conclusion HPV is not a major factor in the carcinogenesis of AEG type Ⅱ , AEG type Ⅲ or stomach.
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