You Position: Home > Paper
Attention should be paid to clinical research of ischemic preconditioning
( views:144, downloads:16 )
- Author:
- No author available
- Journal Title:
- NATIONAL MEDICAL JOURNAL OF CHINA
- Issue:
- 35
- DOI:
- 10.3760/j.issn:0376-2491.2007.35.001
- Key Word:
- No keyword available
Abstract： @@ 缺血缺氧(缺血/氧)性损伤是指氧供下降或氧耗量增加引起的细胞代谢,继而使细胞功能和形态的改变.缺血与缺氧过程并不完全相同,但都具有缺氧的基本特征,因此我们在本文中提到的缺血/氧概指缺血与缺氧两种刺激.缺血/氧常发生于心脑血管意外、器官移植、胎儿宫内窘迫等,因此,对其病理生理及其保护措施的研究长期吸引着国内外医学工作者的关注.1986年,Murry等[1]首次提出"预处理"概念:在细胞或器官经历数次短暂亚致死性缺血/氧以后,再经历长时间的严重缺血/氧,可以明显减轻其损害作用.
- [1]Vasile B,Rasulo F,Candiani A,etc.The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome.[J].2003,29(9).
- [2]D W, Marion,Y, Leonov,M, Ginsberg,etc.Resuscitative hypothermia.[J].1996,24.
- [3]Kolar F,Ostadal B,Neckar J.Myocardial infarct size-limiting effect of chronic hypoxia persists for five weeks of normoxic recovery[J].2004,53(6).
- [4]C E, Murry,R B, Jennings,K A, Reimer.Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.[J].1986,74.
- [5]Z, Cai,J D, Fratkin,P G, Rhodes.Prenatal ischemia reduces neuronal injury caused by neonatal hypoxia-ischemia in rats.[J].1997,8.
- [6]Bishai JM,Oberg KC,Power GG,etc.Absence of robust ischemic preconditioning by five 1-minute total umbilical cord occlusions in fetal sheep.[J].2004,11(7).
- [7]Baker JE.Erythropoietin mimics ischemic preconditioning.[J].2005,42(5).
- [8]Wernecke KD,Weih M,Einhaupl KM,etc.Attenuated stroke severity after prodromal TIA: a role for ischemic tolerance in the brain?[J].1999,30(9).