Association of monocyte chemoattractant protein-1 and the clinical characteristics of polycystic ovary syndrome: analysis of 65 cases
- Author:
- No author available
- Journal Title:
- NATIONAL MEDICAL JOURNAL OF CHINA
- Issue:
- 11
- DOI:
- 10.3760/j:issn:0376-2491.2007.11.001
- Key Word:
- 多囊卵巢综合征;单核细胞趋化蛋白-1;胰岛素抵抗
Abstract： 目的 探讨多囊卵巢综合征(PCOS)患者血清中单核细胞趋化蛋白(MCP)-1浓度的变化及其与PCOS患者临床特征的关系.方法 将PCOS患者和对照者根据体重指数分为PCOS肥胖组(27例)、PCOS非肥胖组(38例)及肥胖对照组和非肥胖对照组(后两组各20例).应用ELISA方法检测PCOS组及对照组血清中MCP-1水平,应用化学发光法检测血清泌乳素、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇和睾酮,应用放射免疫方法检测血清雄烯二酮水平;同时检测空腹血糖和空腹胰岛素.结果 (1)非肥胖PCOS组血清中MCP-1水平明显高于非肥胖对照组[(98±67)ng/ml vs(58±41)ng/ml,P＜0.05].(2)Pearson相关分析显示,MCP-1与体重指数(r=0.339,P=0.000)、LH(r=0.224,P=0.024)及稳态模型的胰岛素抵抗指数(HOMA-IR,r=0.239,P=0.016)呈正相关,与胰岛素敏感指数(ISI)呈负相关(r=-0.250,P=0.011);排除体重指数影响后的偏相关分析显示,MCP-1与LH(r=0.2873,P=0.0006)呈正相关,与其他临床指标之间无明显相关(P＞0.05).(3)多元回归分析结果显示,体重指数(t=3.607,P=0.000)和LH(t=2.298,P=0.024)是影响血清中MCP-1的主要因素,其中体重指数的影响因素更明显.结论 PCOS患者血清中MCP-1水平的升高与LH有关;PCOS可能是一种慢性炎症性疾病;MCP-1可能参与了PCOS患者的肥胖、高胰岛素血症和胰岛素抵抗的发生.
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