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沙鼠脑缺血再灌注损伤后血清脑红蛋白变化
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- Author:
- No author available
- Journal Title:
- NATIONAL MEDICAL JOURNAL OF CHINA
- Issue:
- 28
- DOI:
- 10.3760/j:issn:0376-2491.2005.28.016
- Key Word:
- No keyword available
Abstract： @@ 脑红蛋白是新发现的携氧珠蛋白,在脑和视网膜中高表达,与神经细胞对氧的摄取和利用密切相关[1,2].我们曾研究了沙鼠急性脑缺血后脑红蛋白在脑内的表达变化,发现其可在急性缺血的情况下上调,在脑的适应性保护中起重要作用[3].但目前尚少见关于脑损伤后脑红蛋白在血清中变化情况的报道.本研究拟通过沙鼠脑缺血再灌注模型研究脑损伤后脑红蛋白在血清中的动态变化情况,以期为相关损伤提供新的血清学检测或诊断指标.
- [1]孙健伟,韩洪彦,徐文琳,等.大鼠脑红蛋白（NGB）可溶性原核表达和单克隆抗体制备及鉴定[J].2003,(6).
- [2]尚爱加,周定标,高艳,等.沙鼠前脑缺血后脑红蛋白的表达变化[J].2004,(16).
- [3]Wolfrum U,Giessl A,Schmidt M,etc.How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina.[J].2003,278(3).
- [4]R. T. CUNNINGHAM,M. WATT,J. WINDER,etc.Serum neurone-specific enolase as an indicator of stroke volume[J].1996,26(4).
- [5]Sun Y,Zhu Y,Jin K,etc.Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury.[J].2001,98(26).
- [6]T, Burmester,B, Weich,S, Reinhardt,etc.A vertebrate globin expressed in the brain.[J].2000,407(6803).
- [7]Wunderlich MT,Ebert AD,Kratz T,etc.Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage.[J].1999,30(6).
- [8]Peel A,Sun Y,Greenberg DA,etc.Neuroglobin protects the brain from experimental stroke in vivo.[J].2003,100(6).
- [9]Chenggang, Zhang,Chunli, Wang,Meiyu, Deng,etc.Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin.[J].2002,290(5).