Abstract： Objective To study the clinical features and the pathogenesis of macular hole with and without retina detachment(RD)in high myopic eyes.Methods It was a retrospective series case study.The charts of high myopic patients with macular hole at our hospital from June 2006 to February 2007 were retrospectively reviewed and analyzed. Patients were divided into two groups (the RD group and non-RD group) depending on the presence of RD or not. Their clinieal data and optic coherence tomography (OCT)results were further analyzed. SPSS 13.0 was used for the statistic analysis. When comparing the quantitative aspects like age, axial length and refraction, t-test was used. Categorical data, such as sex ratio, occurrence of vitreous traction, posterior staphyloma and retinoschisis were compared by using X2 test. Fisher's test was used in comparing eye laterality, incidence of white hole, visual acuity and posterior vitreous detachment (PVD). Results During this period, there were 43 patients fitting the including criteria. Among them,36 patents (37 eyes) were in the RD group and 7 patients (7 eyes) in the no-RD group. In the RD group,the average age was 56. 1,24. 3% of them (9/37) were male;percentage of left and right eyes was (11/37)and 70. 3% (26/37), respectively; average refraction was ( -8.9 ± 2. 2) D; average axial length was (28.7 ±2. 0) mm. Visual acuity was ≤0. 05 (72. 2% ) in 26 eyes and 0. 05-0. 2 (27. 8%) in 10 patients.The incidence of complete and non-complete PVD was 89. 2% (33/37) and 10. 8% (4/37), respectively.White hole presented in 35.1% (3/37) patients. Vitreous traction and retinoschisis presented in 27. 0%(10/37) and 35. 1% (13/37) patients, respectively. In the non-RD group, the average age was 47. 6;16. 7% of them (1/7) were male; left and right eyes were involved in 42. 9% (3/7) and 57. 1% (4/7),respectively. Average refraction was ( -9. 0 ± 1.9) D; average axial length was ( 28.9 ± 1.5 ) mm. Vision acuity was ≤0.05 in 3 patients (42.9%); between 0.05-0.2 in 3 eyes (42.9%) and ≥0.2 in 1 eye (14. 3% ). Incidence of complete and non-complete PVD was 85.7% (6/7) and 14. 3% (1/7),respectively. White hole was observed in 14. 3% (1/7) patients; 42. 9% (3/7) patients were accompanied with vitreous traction and 71.4% (5/7) with retinoschisis. B-scan ultrasenography showed posterior staphyloma in all 44 eyes. The results of statistical analysis showed that the gender (X2 = 0.008) and eye laterality (X2=0.449) as well as refraction (t=0.193), axial length (t=-0.25) and visual acuity (X2=4.509) of these two groups were similar (P>0.05). The incidences of vitreous traction (X2=0. 709), white hole (X2=1.179 ), PVD (X2=0.071) and retinoschisis (X2=3.207) were also similar (P>0. 05). But the age of the non-RD group is significantly younger than the RD group (t=1.66,P<0. 05). Conclusions Various pathogenesis may involved in the occurrence of retinal detachment in highly myopic eyes with macular hole. Further study is required to improve our understanding of this entity.