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糖基化对牛α-晶状体蛋白分子伴娘功能的作用
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OPHTHALMOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j:issn:0412-4081.2004.09.014
- Key Word:
- No keyword available
Abstract： @@ α-晶状体蛋白作为晶状体的主要结构蛋白,是维持晶状体结构和屈光特性的重要物质,其分子伴娘功能对保护晶状体透明具有决定性作用.糖基化可修饰α-晶状体蛋白,影响其分子伴娘功能,参与年龄相关性白内障和糖尿病性白内障的形成[1,2].本研究通过观察6-磷酸果糖(fructose-6-phosphate,F6P)和核糖对α-晶状体蛋白的修饰和影响,证实糖基化在白内障形成中的作用机制.
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- [2]M. Cherian,E.C. Abraham.Diabetes Affects α-Crystallin Chaperone Function[J].1995,212(1).
- [3]Harding JJ,Derham BK.Effects of modifications of alpha-crystallin on its chaperone and other properties[J].2002,364(Pt.3).
- [4]Robert Blakytny,John A Carver,John J Harding,etc.A spectroscopic study of glycated bovine α-crystallin: investigation of flexibility of the C-terminal extension, chaperone activity and evidence for diglycation[J].1997,1343(2).