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Antiproliferative effect of sustained drug delivery system of all-trans retinoic acid implant into rabbit′s vitreous cavity for treatment of proliferative vitreoretinopathy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OPHTHALMOLOGY
- Issue:
- 10
- DOI:
- 10.3760/cma.j.issn.0412-4081.2003.10.114
- Key Word:
- 维甲酸;迟效剂;玻璃体视网膜病,增生性
Abstract： 目的探讨全反式维甲酸(atRA)缓释系统玻璃体腔植入对实验性增殖性玻璃体视网膜病变(PVR)的预防作用.方法采用中轴部玻璃体切除联合成纤维细胞注入术构建兔PVR模型.术中3组兔眼玻璃体腔均分别植入不同含量的atRA缓释系统:B组缓释系统atRA含量为420 μg,C组缓释系统atRA 含量为 650 μg,D组缓释系统atRA 含量为1 070 μg;设空白对照两组:A组不植入atRA缓释系统,E组玻璃体腔植入空白atRA缓释系统.植入后共观察8周,每周抽取玻璃体腔液进行atRA含量检测.8周后行组织病理学检查.结果术后8周,植入atRA含量 650 μg和1 070 μg缓释系统组,兔眼PVR程度低于其他各组,经统计学分析差异有显著意义(P<0.05),组织病理学检查未见眼内毒性反应.结论 atRA缓释系统玻璃体腔给药方便、安全.atRA抑制PVR能力与玻璃体腔药物浓度相关,atRA含量为650 μg和1 070 μg缓释系统植入玻璃体腔可有效预防术后PVR发生,而atRA含量为420 μg缓释系统植入玻璃体腔仅能抑制和延缓PVR发生.
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