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The role of taurine as hydroxyl radical inhibitor and its effect on lipid peroxidation in selenite cataract
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF OPHTHALMOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j:issn:0412-4081.2002.03.009
- Key Word:
- 白内障;牛磺酸;自由基;丙二醛
Abstract： 目的探讨牛磺酸对体外反应系统中的羟自由基和超氧阴离子自由基的清除作用;观察腹腔注射牛磺酸对大鼠亚硒酸钠性白内障晶状体中脂质过氧化的影响.方法应用电子自旋顺磁共振技术,检测不同浓度的牛磺酸对羟自由基和超氧阴离子自由基的清除作用.在注射亚硒酸钠后第2、5、9和14天,分别测定正常组、亚硒酸钠组和牛磺酸组大鼠晶状体中的丙二醛(malondialdehyde,MDA)含量.结果牛磺酸对羟自由基和超氧阴离子自由基具有明显的清除作用.大鼠注射亚硒酸钠后,其晶状体中MDA的含量较正常晶状体明显升高,并随着白内障病程的发展逐渐增加.牛磺酸组晶状体中MDA的含量始终低于亚硒酸钠组.结论牛磺酸对羟自由基、超氧阴离子自由基具有明显的清除作用;对亚硒酸钠性白内障晶状体中的脂质过氧化反应具有明显的抑制作用.
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