Abstract： Objective To analyze the epidemiology status and risk factors of disabilities caused by injury in Guangdong province. Methods Stratified multi-stage cluster sampling was used to identify 1530 subjects with disabilities (among them,415 disabilities caused by injury) ,in the villages or districts in the four regions of Guangzhou, Qingyuan, Zhaoqing and Huizhou in 2010. Subjects were interviewed by trained staff with self-made questionnaires about the status of the disabled ,then 415 disabled caused by injury were interviewed about the process of the injury causing disability. The variables in this survey included gender,regions,rural (urban) residences, occupation, age and injury style. The difference of injury were analyzed through x2 test,and the influencing factors were explored through classification tree model. Results The top five causes of disability were road traffic injury, fall, work-related injury, medical accident, scald or burn,accounting for 32.53 ％ ( 135/415 ), 21.45％ ( 89/415 ), 12.77％ ( 53/415 ), 8. 43％ ( 35/415 ) and 5.06％ (21/415) ,respectively. The proportion of male was higher than female in all disabilities caused by injury (295 male, 117 female, 3 unknown ). Female had higher proportion 8.55％ ( 10/117 ) than male 3.05％ (9/295)with the cause of scald or burn ( x2 =6.302,P =0.012) ,the proportion of rural residents 38.89％ (84/216)was also higher than urban residents 25.63％ (51/199)in disabilities caused by traffic accident (x2 =43.850,P ＜ 0.001 ); and the proportion of rural residents 25.46％ (55/216)was also higher than urban residents 8.55％ (34/199) in disabilities caused by the fall ( x2 = 8.257, P = 0.004 ). Different age groups and regions had different types of injury causing disability,53.08％ (69/130) traffic accident and 51.92％ (27/52) work-injury mainly caused disability in 25 - 44 age group, 85.71％ ( 30/35 ) medical accident and 76.20％ ( 16/21 ) scald or burn mainly caused disability in 0 - 14 age group, the injury caused by the fall was 62.50％ (5/8) in 65 - age group. The proportions of fall in Qingyuan 29.09％ (16/55) and Huizhou 28.23％ ( 37/131 ) were significantly higher than that in Guangzhou 13.38％ ( 21/157 ) and Zhaoqing 21.13％ ( 15/71 ) (x2 = 11.904, P= 0.008) .The proportions of work-injury in Guangzhou 19.11％ (30/157) and Zhaoqing 19.72％ ( 14/71 ) were significantly higher than that in Qingyuan 0.00％ (0/55) and Huizhou 6.09％ ( 8/131 ) ( x2 = 22.309, P ＜ 0.001 ). The proportions of disabled by scald or burn in Guangzhou 10.83％ ( 17/157 ) and Qingyuan 0.00％ (0/55) were significantly higher than that in Zhaoqing 1.41％ ( 1/71 ) and Huizhou 2.27％ (3/131 ) ( x2 = 17.826, P ＜ 0.001 ). Classification tree model revealed that the age group, occupation and urban-rural were major factors influencing intended harm, the highest proportion of the intended harm was in 25 -44 age group (59.21％, 151/255 ). Conclusion The road traffic injury,fall,work-related injury,medical accident and scald or burn were main causes of disability in Guangdong province. Gender, age, and urban-rural factors were associated with disabilities caused by injury.