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Research progress of pyroptosis in the pathogenesis of retinal diseases

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Author:: No author available

Journal Title:: Chinese Journal of Ocular Fundus Diseases

Issue:: 11

DOI:: 10.3760/cma.j.cn511434-20210409-00187

Key Word:: 细胞焦亡;糖尿病视网膜病变;黄斑变性;综述;Pyroptosis;Diabetic retinopathy;Macular degeneration;Review

Abstract： Pyroptosis is an inflammatory form of programmed cell death, including canonical and non-canonical pyroptosis pathway. Studies on pyroptosis have been reported in a variety of retinal diseases, but they are more focused on common diseases such as diabetic retinopathy and age-related macular degeneration. Many retinal diseases are difficult to treat because of the complexity of their etiology and pathogenesis. The discovery of pyroptosis has brought new content to the pathogenesis of these diseases, and also pointed a new direction for the treatment. Pyroptosis does not occur independently, and it is related to apoptosis and autophagy, but the specific mechanism is not clear. However, the most important biomolecule in the process of pyroptosis have been basically determined, and some methods can be used to interfere with pyroptosis, which has obtained preliminary achievement, suggesting that inhibition of pyroptosis may be a new direction for the treatment of retinal diseases and has broad research prospects.

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