Paper - WANFANG MED ONLINE

You Position: Home > Paper

The present research and progress of angiopoietin in diabetic retinopathy

( views:27, downloads:1 )

Author:: No author available

Journal Title:: Chinese Journal of Ocular Fundus Diseases

Issue:: 11

DOI:: 10.3760/cma.j.cn511434-20210707-00364

Key Word:: 血管生成素类;糖尿病视网膜病变;受体蛋白质酪氨酸激酶类;脂质代谢;综述;Angiopoietins;Diabetic retinopathy;Receptor protein-tyrosine kinases;Lipid metabolism;Review

Abstract： Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes, and it is the main cause of vision loss in diabetic patients. Angiopoietin (Ang), a superfamily of secreted proteins, is a vascular growth factor that regulates the stability of vascular environment, participates in angiogenesis and repair, and lipid metabolism. It plays an important role in the development of DR and has become a new target for the treatment of diabetic retinopathy. With the in-depth study of Ang and the research and development of various drugs for Ang, it is expected to bring new ideas and strategies for the treatment of DR in the future.

Reference

[1]Cai-Guo Yu,Sha-Sha Yuan,Long-Yan Yang,etc.Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients[J].2018,191.
[2]Nicolini, Giuseppina,Forini, Francesca,Kusmic, Claudia,etc.Angiopoietin 2 signal complexity in cardiovascular disease and cancer[J].2019,239.
[3]Raquel Lima E, Silva,Yogita, Kanan,Adam C, Mirando,etc.Tyrosine kinase blocking collagen IV-derived peptide suppresses ocular neovascularization and vascular leakage.[J].2017,9(373).
[4]Michael Whitehead,rew Osborne,Peter S. Widdowson,etc.Angiopoietins in Diabetic Retinopathy: Current Understanding and Therapeutic Potential[J].2019,2019.
[5]Elisa Gomez Perdiguero,Athanasia Liabotis‐Fontugne,Mélanie Durand,etc.ANGPTL4–αvβ3 interaction counteracts hypoxia‐induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2[J].2016,240(4).
[6]Khalaf, Nervana,Helmy, Hazem,labib, Hany,etc.Role of Angiopoietins and Tie-2 in Diabetic Retinopathy.[J].2017,9(8).
[7]Rochfort, Keith D.,Carroll, Lara S.,Barabas, Peter,etc.COMP-Ang1 Stabilizes Hyperglycemic Disruption of Blood-Retinal Barrier Phenotype in Human Retinal Microvascular Endothelial Cells[J].2019,60(10).
[8]Sahni, Jayashree,Dugel, Pravin U.,Patel, Sunil S.,etc.Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration The AVENUE Phase 2 Randomized Clinical Trial[J].2020,138(9).
[9]Joussen, Antonia M.,Ricci, Federico,Paris, Liliana P.,etc.Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data[J].2021,35(5).
[10]Richard H,Foxton,Sabine,Uhles,Sabine,Grüner,etc.Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization.[J].2019.
[11]Park Do Young,Lee Junyeop,Kim Jaeryung,etc.Plastic roles of pericytes in the blood–retinal barrier[J].2017,8(1).
[12]Marco Bruno Morelli,Christopher Chavez,Gaetano Santulli.Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders[J].2020,24(1).
[13]Park,S.W.,Yun,J.-H.,Kim,J.H.,etc.Angiopoietin 2 induces pericyte apoptosis via α3β1 integrin signaling in diabetic retinopathy[J].2014,63(9).
[14]邵彦,李筱荣.从能量代谢角度看糖尿病相关眼病的诊疗[J].2020,(9).
[15]Judd M Cahoon,Ruju R Rai,Lara S Carroll,etc.Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy.[J].2015,64(12).
[16]Babapoor-Farrokhran, Savalan,Jee, Kathleen,Puchner, Brooks,etc.Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy[J].2015,112(23).
[17]Chang-Xia Dong,Cai-Ping Song,Chun-Ping Zhang,etc.Clinical and experimental study on angiopoietin-like protein 8 associated with proliferative diabetic retinopathy[J].2017,(12).
[18]Ehrlich, Kenneth C.,Lacey, Michelle,Ehrlich, Melanie.Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes[J].2019,11(2).
[19]Nancy M. Holekamp,Joanna Campbell,Arghavan Almony,etc.Vision Outcomes Following Anti–Vascular Endothelial Growth Factor Treatment of Diabetic Macular Edema in Clinical Practice[J].2018,191.
[20]Menden, Heather,Welak, Scott,Cossette, Stephanie,etc.Lipopolysaccharide (LPS)-mediated Angiopoietin-2-dependent Autocrine Angiogenesis Is Regulated by NADPH Oxidase 2 (Nox2) in Human Pulmonary Microvascular Endothelial Cells[J].2015,290(9).
[21]Adam C,Mirando,Jikui,Shen,Raquel Lima E,Silva,etc.A collagen IV-derived peptide disrupts α5β1 integrin and potentiates Ang2/Tie2 signaling.[J].2019,4(4).
[22]Jie Kai Tee,Magdiel Inggrid Setyawati,Fei Peng,etc.Angiopoietin-1 accelerates restoration of endothelial cell barrier integrity from nanoparticle-induced leakiness[J].2019,13(5).
[23]Khanani, Arshad M.,Patel, Sunil S.,Ferrone, Philip J.,etc.Efficacy of Every Four Monthly and Quarterly Dosing of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration The STAIRWAY Phase 2 Randomized Clinical Trial[J].2020,138(9).
[24]Rehan M. Hussain,Ashley E. Neiweem,Viral Kansara,etc.Tie-2/Angiopoietin pathway modulation as a therapeutic strategy for retinal disease[J].2019,28(10).
[25]Xinyue,Yang,Jinfeng,Cao,Yang,Du,etc.Angiopoietin-Like Protein 4 (ANGPTL4) Induces Retinal Pigment Epithelial Barrier Breakdown by Activating Signal Transducer and Activator of Transcription 3 (STAT3): Evidence from ARPE-19 Cells Under Hypoxic Condition and Diabetic Rats.[J].2019,25.
[26]Nguyen Quan Dong,Heier Jeffrey S.,Do Diana V.,etc.The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye[J].2020,6(1).
[27]Keles Ali,Sonmez Kenan,Erol Yasemin Ozdamar,etc.Vitreous levels of vascular endothelial growth factor, stromal cell–derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy[J].2020,259(1).
[28].Angiopoietin-1 suppresses choroidal neovascularization and vascular leakage[J].2014,55(4).
[29]Saharinen Pipsa,Eklund Lauri,Alitalo Kari.Therapeutic targeting of the angiopoietin–TIE pathway[J].2017,16(9).
[30].New Therapies of Neovascular AMD beyond Anti-VEGF Injections[J].2018,2(1).
[31]Amnah Siddiqa,Elisa Cirillo,Samar H.K. Tareen,etc.Visualizing the regulatory role of Angiopoietin-like protein 8 (ANGPTL8) in glucose and lipid metabolic pathways[J].2017,109(5/6).
[32]Yun, Jang-Hyuk,Han, Man Hyup,Jeong, Han-Seok,etc.Angiopoietin 1 attenuates interleukin-6-induced endothelial cell permeability through SHP-1[J].2019,518(2).
[33]Lu, Qianyi,Zou, Wenjun,Chen, Bin,etc.ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy[J].2016,254(7).
[34]Najia Jin,William F. Matter,Laura F. Michael,etc.The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage[J].2021,16(3).
[35]Yang, Long-Yan,Yu, Cai-Guo,Wang, Xu-Hong,etc.Angiopoietin-Like Protein 4 Is a High-Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type-2 Diabetic Patients[J].2017,6(6).
[36]Campochiaro Peter A.,Peters Kevin G..Targeting Tie2 for Treatment of Diabetic Retinopathy and Diabetic Macular Edema[J].2016,16(12).