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p21在氧诱导视网膜新生血管模型小鼠视网膜中的表达
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Ocular Fundus Diseases
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1005-1015.2011.06.025
- Key Word:
- 周期素依赖激酶抑制剂p21;视网膜新生血管化/病因学;基因表达;疾病模型,动物
Abstract： 视网膜新生血管(RNV)生成主要依赖于血管内皮细胞的不断分裂、增生[1].p21是细胞周期中重要的负性调控因子,能够广泛结合并抑制各种细胞周期蛋白依赣性激酶(CDK)复合物的磷酸化活性,主要参与细胞周期中G1/S期的调控,使细胞阻滞于G1期进而抑制细胞增生[2].有研究发现,p21在细胞异常增生性疾病中处于低表达[3].为探讨p21在RNV形成过程中的作用及机制,我们观察了p21和CDK2在氧诱导RNV小鼠视网膜中的表达.现将结果报道如下.
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