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妊娠早、中期血清25-羟维生素D3水平与子痫前期发生风险的关系
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Perinatal Medicine
- Issue:
- 11
- DOI:
- 10.3760/cma.j.issn.1007-9408.2014.11.010
- Key Word:
- 子痫前期;维生素D,25-羟维生素D3
Abstract： 目的 探讨妊娠早、中期血清25-羟维生素D3水平与子痫前期发病的关系. 方法 采用病例对照研究方法.选择2012年1月至2013年1月于山东省聊城市妇幼保健院进行产前检查的无合并症的初产妇1 187例,于妊娠早期(妊娠10～12周)及中期(妊娠18～20周)留取静脉血标本.其中79例孕妇妊娠20周后诊断为子痫前期.按1:2配对原则从另外1 108例孕妇中选择年龄相似、末次月经时间相近的健康孕妇1 58例作为对照组.采用电化学发光免疫法检测血清25-羟维生素D3水平.统计学分析采用两独立样本t检验和Logistic回归分析. 结果 子痫前期组与对照组妊娠早期血清25-羟维生素D3水平差异无统计学意义[(26.9±3.2)与(27.6±2.8)μg/L,t=1.729,P=0.085],而妊娠中期子痫前期组孕妇25-羟维生素D3水平较对照组明显降低[(23.3±2.5)与(26.7±3.8)μg/L,t=7.217,P=0.001].妊娠早期和中期,25-羟维生素D3缺乏(＜20μg/L)的孕妇发生子痫前期的风险分别是25-羟维生素D3充足(≥30μg/L)孕妇的1.87倍(95％CI:1.16～3.92,P-0.04)和3.06倍(95％CI:1.16～4.50,P=0.04). 结论 妊娠早、中期血清25-羟维生素D3缺乏孕妇发生子痫前期的风险升高.
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