You Position: Home > Paper
可溶性血管内皮生长因子受体-1在重度子痫前期患者胎盘组织中的表达及意义
( views:307, downloads:208 )
- Author:
- No author available
- Journal Title:
- Chinese Journal of Perinatal Medicine
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2012.05.008
- Key Word:
- No keyword available
Abstract： 子痫前期是妊娠期特有疾病,胎盘形成或母体对胎盘的反应是子痫前期发生的中心环节[1],但具体发病机制尚不十分明确.最近研究发现,循环中可溶性血管内皮生长因子受体-1(soluble fms-like tyrosine kinase-1,sFlt-1)过量表达可能与重度子痈前期的发生发展密切相关[2],sFlt-1过度表达可阻断血管内皮生长因子(vascular endothelial growth factor,VEGF)的生物学作用,造成全身内皮功能失调,产生高血压、蛋白尿等重度子痫前期的表现.故本研究通过免疫组织化学方法,检测胎盘组织中sFlt-1蛋白的表达,探讨重度子痫前期患者胎盘组织中sFlt-1的表达部位、表达水平及其意义.
- [1]陈红.子痫前期胎儿生长受限危险因素的Logistic回归分析[J].2011,(2).
- [2]赵晓曦.孕妇血中胎儿细胞和游离胎儿核酸的变化与子痫前期预测[J].2011,(7).
- [3]Ferrara N,Eremina V,Hochster H,etc.VEGF inhibition and renal thrombotic microangiopathy.[J].2008,358(11).
- [4]Makrina D. Savvidou,Christina K. Yu,Lisa C. Harland,etc.Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction[J].2006,195(6).
- [5]乐杰主编.妇产科学[M].1999.
- [6]Mammoto T,Libermann TA,Hanai J,etc.Soluble endoglin contributes to the pathogenesis of preeclampsia.[J].2006,12(6).
- [7]Stillman IE,Epstein FH,Sellke FW,etc.Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia.[J].2003,111(5).
- [8]Sarosh Rana,Alice Wang,S. Ananth Karumanchi.Preeclampsia: The Role of Angiogenic Factors in Its Pathogenesis[J].2009,24(Jun).
- [9]Wikstrom AK,Eriksson UJ,Nash P,etc.Placental growth factor and soluble FMS-like tyrosine kinase-1 in early-onset and late-onset preeclampsia.[J].2007,109(6).
- [10]Grandaliano G,Schena FP,Schena A,etc.Increased placental expression of tissue factor is associated with abnormal uterine and umbilical Doppler waveforms in severe preeclampsia with fetal growth restriction.[J].2003,16(5).
- [11]Maharaj AS,D'Amore PA.Roles for VEGF in the adult.[J].2007,74(2).
- [12]Robinson CJ,Stringer SE.The splice variants of vascular endothelial growth factor (VEGF) and their receptors.[J].2001,114(Pt.5).