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胰岛素样生长因子-1与胎儿生长发育关系的研究
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Perinatal Medicine
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1007-9408.2012.05.007
- Key Word:
- No keyword available
Abstract： 胎儿宫内的生长发育受多种因素影响,包括遗传、营养、生长激素及环境等方面.尽管进行了广泛的研究,胎儿生长发育中起重要作用的内分泌机制仍未完全阐明.胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)是由70个氨基酸组成的单链碱性蛋白,具有胰岛素样生物活性,参与糖、脂肪、蛋白质的代谢,并可促进细胞增殖分化,抑制细胞凋亡.近年来研究发现IGF-1是妊娠早期胚胎发育的重要调节因子之一,并推测其可能参与妊娠中晚期胎儿生长发育的调节[1].本研究通过对母体血清中IGF-1的含量、胎儿脐血以及胎盘组织中IGF-1 mRNA和蛋白的表达量进行测定,以进一步探讨IGF-1与胎儿生长发育的关系.
- [1]吴琦嫦,刘运科,刘斌.胰岛素样生长因子1及胰岛素样生长因子结合蛋白3与胎儿生长发育的关系[J].2002,(3).
- [2]刘虹,梁雪雯,王彦德.瘦素及胰岛素样生长因子-Ⅰ与胎儿生长受限的关系[J].2004,(6).
- [3]周英,李明霞.早期营养摄入对早产儿瘦素、胰岛素样生长因子-1及生长激素的影响[J].2007,(2).
- [4]Regina, Trollmann,Karin, Klingmüller,Ralf L, Schild,etc.Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta.[J].2007,197(6).
- [5]C S, Mantzoros.The role of leptin in human obesity and disease: a review of current evidence.[J].1999,130(8).
- [6]I?iguez,G.,González,C.A.,Argando?a,F.,etc.Expression and protein content of IGF-I and IGF-I receptor in placentas from small, adequate and large for gestational age newborns[J].2010,73(5).
- [7]Koken T,Saylan F,Sahin F,etc.Maternal and fetal leptin and ghrelin levels: relationship with fetal growth.[J].2011,284(2).
- [8]Verhaeghe J,Billen J,Giudice LC.Insulin-like growth factor-binding protein-1 in umbilical artery and vein of term fetuses with signs suggestive of distress during labor.[J].2001,170(3).
- [9]乐杰.妇产科学[M].1980.
- [10]Park MH,Kim YJ,Jeon YJ,etc.Placental gene expression is related to glucose metabolism and fetal cord blood levels of insulin and insulin-like growth factors in intrauterine growth restriction.[J].2010,86(1).
- [11]Bhartiya D,Satoskar P,Sheikh S.Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: a comparison between normal and intrauterine growth retardation pregnancies.[J].2001,7(3).
- [12]Nielsen HC,Chetty A.Regulation of Cell Proliferation by Insulin-like Growth Factor 1 in Hyperoxia-Exposed Neonatal Rat Lung.[J].2002,75(3).
- [13]Osmond C,Miell JP,Thame M,etc.The Relationship among Circulating Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins-1 and -2, and Birth Anthropometry: A Prospective Study.[J].2003,88(4).