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造血干细胞移植诱导肾移植物免疫耐受的研究进展

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Author:: No author available

Journal Title:: Chinese Journal of Organ Transplantation

Issue:: 8

DOI:: 10.3760/cma.j.issn.0254-1785.2015.08.014

Key Word:: No keyword available

Abstract：新免疫抑制剂明显提高了移植物的短期存活率,但移植器官的远期存活率与几十年前相比却无明显改善,这主要与移植器官的慢性排斥反应和长期使用免疫抑制剂带来的不良反应有关,尤其是慢性排斥反应,它已成为移植肾功能丧失的主要原因.诱导移植器官免疫耐受可避免长期的免疫抑制治疗和慢性排斥反应,本文对造血干细胞移植诱导临床肾脏耐受进行综述,以期为临床移植器官耐受实验的开展提供参考.

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