Abstract： Objective To investigate the changes of renal function in living related kidney donors.Methods 102 living related donor kidney transplantations were performed at our center from Jan.2000 to Jan.2008.All of the follow-up data were collected to investigate the changes of renal function in living related kidney donors.Living kidney donors underwent a comprehensive inspection pre-and post-operation,including blood regular test,serum creatinine,blood urea nitrogen,glomerular filtration rate and urine protein,and then regular followed-up after operation.All of the indexes were compared to themselves before operation.Results 102 operations were performed successfully.and none of the living related donors died.There were 32 male and 70 female donors with mean age of 51.7 years(34-62).Nephreetomy on 90 left and 12 right sides was done.Seventyfour donors underwent laparoscopic nephrectomy and the others were subjected to open nephrectomy.All donors were followed up from 3 to 99 months (mean 37.8 months).The hemoglobin level was decreased post-operation and had significant difference on the first day,and first week compared to pre-operation.The RBC count had also significant difference within two weeks.The blood urea nitrogen level was increased significantly compared to preoperative level.There was significant difference in serum creatinine level before and after operation(P<0.05),but none of the indexes exceeding normal range.After operation,GFR of donors was increased to varying degrees as compared with that before operation.Starting from the postoperative weeks 2,there was significant difference GFR in comparison to that before operation(P<0.05).The rate of the increase in GFR at the 3rd month after operation was the largest. Urinary protein had no positive findings.Conclusion The renal function in living related kidney donors is not influenced after operation.The serum creatinine level is elevated to varying degrees after operation,but still within normal limits.The GFR level has a compensatory elevation.