Abstract： Objective discuss the prevention and management of ischemic cardiomyopathy in the early stage after liver transplantation. Methods The clinical data of 18 patients with ischemic cardiomyopathy after liver transplantation were analyzed retrospectively. The initial symptoms of the 18 patients were precordia pain with palpitations and sweating. The electrocardiogram showed ST-T continuous changes and the myocardial enzyme increased. As soon as the diagnosis of ischemic cardiomyopathy was established, nitroglycerin, anticoagulation, and sedative treatment were provided to the patients. Results Sixteen patients recovered, and 2 developed into myocardial infarction and died. Conclusion The accurate assessment before operation, anticoagulation in the early stage, adequate sedation, optimization of the liquid load, normal hematocrit and the use of nitroglycerin are effective ways to reduce the morbidity and mortality of ischemic cardiomyopathy after liver transplantation.