You Position: Home > Paper
成人胰岛细胞移植的临床进展
( views:170, downloads:32 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2008.04.020
- Key Word:
- No keyword available
Abstract： @@ 糖尿病是因胰岛素分泌缺乏和(或)胰岛素作用缺陷而引起以血糖水平增高为特征的代谢疾病.现有的治疗方法并不能逆转糖尿病的发病过程,患者最终多因慢性并发症致残或致死,严重危害人类健康.自2000年加拿大Shapiro等[1]报道采用成人胰岛细胞移植成功治愈7例1型糖尿病(T1DM)以来,使胰岛细胞移植再次成为全球研究的热点课题.本文着重介绍该项技术的临床现状与进展.
- [1]Ricordi C.,Lacy P. E.,Scharp D. W..Automated Islet Isolation From Human Pancreas[J].1989.
- [2]Moore A,Bonner Weir S,Medarova Z,etc.In vivo imaging of islet transplantation.[J].2006,12(1).
- [3]Hering BJ,Brendel MD,Suther,etc.International trial of the Edmonton protocol for islet transplantation.[J].2006,355(13).
- [4]R M, Jindal.Posttransplant diabetes mellitus--a review.[J].1994,58(12).
- [5]Bonner Weir S,McEwan AJ,Shapiro AM,etc.Toward development of imaging modalities for islets after transplantation: insights from the national institutes of health workshop on beta cell imaging.[J].2004,77(8).
- [6]Ricordi C,Pileggi A,Alessiani M,etc.Factors influencing Islet of Langerhans graft function and monitoring.[J].2001,310(1).
- [7]D E, Sutherland,A J, Matas,F C, Goetz,etc.Transplantation of dispersed pancreatic islet tissue in humans: autografts and allografts.[J].1980,29.
- [8]A.M. James Shapiro,David Bigam,Edmond A. Ryan,etc.Five-Year Follow-Up After Clinical Islet Transplantation[J].2005,54(7).
- [9]White SA,London NJ,Johnson PR,etc.The risks of total pancreatectomy and splenic islet autotransplantation.[J].2000,9(1).
- [10]Korbutt GS,Lakey JR,Kneteman NM,etc.Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen (see comments)[J].2000,343(4).
- [11]P E, Lacy,M, Kostianovsky.Method for the isolation of intact islets of Langerhans from the rat pancreas.[J].1967,16(1).
- [12]D W, Scharp,P E, Lacy,J V, Santiago,etc.Insulin independence after islet transplantation into type I diabetic patient.[J].1990,39(4).
- [13]Tufveson G.Current Status of Clinical Islet Transplantation.[J].2005,79(10).
- [14]Vantyghem MC.Assessment of the Severity of Hypoglycemia and Glycemic Lability in Type 1 Diabetic Subjects Undergoing Islet Transplantation.[J].2004,53(4).
- [15]Iwanaga Y,Yamada Y,Noguchi H,etc.Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.[J].2005,365(9471).
- [16]Sawada T,Hunter DW,Ansite JD,etc.Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes.[J].2005,293(7).
- [17]W F, Ballinger,P E, Lacy.Transplantation of intact pancreatic islets in rats.[J].1972,72(2).