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胰岛移植后经血液介导的炎症反应
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2004.04.027
- Key Word:
- No keyword available
Abstract： @@ 大量的研究表明,胰岛移植后的初期常伴有大量胰岛的丢失[1],这些现象被统称为原发性无功能,而与免疫因素无关.除了胰岛制备中内在的固有质量因素外,胰岛与肝脏微环境炎症因素之间的相互作用也是导致胰岛丢失的原因.另外,一个很少被重视的原因可能是新植入的胰岛与血流接触的瞬间所引发的反应,被称为立即经血液介导的炎症反应(Instant blood-mediated inflammatory reaction,以下简称IBMIR)[2].IBMIR的特征是血小板的激活和凝血系统以及补体系统的激活,这些瀑布反应导致胰岛的损伤.这种反应有可能解释胰岛功能早期损伤和丢失,也有可能是临床胰岛移植成功率明显比胰腺移植差的原因.本文将就IBMIR的机制、存在的问题及可能的解决方法等方面加以分析.
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