You Position: Home > Paper
Long-term evaluation of FK506 based immunosuppressive therapy in kidney transplantation
( views:324, downloads:109 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.06.120
- Key Word:
- 肾移植;他克莫司;环孢菌素
Abstract： 目的探讨肾移植术后长期应用他克莫司(FK506)的临床疗效和安全性.方法对肾移植术后符合入选条件的126例服用FK506和109例服用环孢素A(CsA)的患者进行为期3年的随访.详细记录了患者的服药剂量、FK506和CsA谷值浓度,观察排斥反应、毒副反应发生率,计算人/肾存活率.结果 FK506组和CsA组1、3年人/肾存活率分别为:98.4%/96.8%、95.2%/90.5%和97.2%/96.3%、94.4%/89.0%;急性排斥反应发生率分别为:13.5%和19.3%(P<0.05);慢性排斥反应发生率分别为:3.2%和8.3%(P<0.05);糖代谢紊乱发生率分别为:16.7%和9.2%(P<0.05);神经精神毒性分别为:14.3%和12.0%;肝功能损害分别为:6.3%和10.1%(P<0.05);肾功能损害分别为:3.2%和8.3%(P<0.05);脱发分别为:5.6%和0(P<0.05);感染分别为:7.1%和6.4%.结论 FK506长期使用疗效确切,毒副反应发生率较低.
- [1]Pichlmayr R,Johnson RW,Talbot D,etc.Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group.[J].1997,64(3).
- [2]J M, Cecka,Y W, Cho,P I, Terasaki.Analyses of the UNOS Scientific Renal Transplant Registry at three years--early events affecting transplant success.[J].1992,53.
- [3]Takahashi K,Fuchinoue S,Toma H,etc.Long-term results of living kidney transplantation under tacrolimus immunosuppression: a single-center experience.[J].1998,30(4).
- [4]Ehlerding G,Pichlmayr R,Kliem V,etc.Tacrolimus for steroid- and OKT3-resistant rejection in kidney recipients.[J].1998,30(4).
- [5]Jensik StephenC,Miller Joshua,Pirsch John,etc.A long-term comparison of tacrolimus (FK506) and cyclosporine in kidney transplantation: evidence for improved allograft survival at five years.[J].2002,73(5).