You Position: Home > Paper
Impact of donor-specific antibodies on kidney graft short-term survival
( views:220, downloads:20 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.06.118
- Key Word:
- 肾移植;抗体特异性;移植物排斥
Abstract： 目的评价肾移植术后供者特异性抗体(Ds-Ab)对移植肾近期效果的影响.方法对2001年1月至2002年7月间进行尸肾移植的92例受者,使用酶联免疫吸附(ELISA)法,检测受者血清中HLA抗体水平,随访1年.结果 16例(17.4%)受者术后出现供者特异性抗体.抗体阳性组急性排斥发生率(56.3%)高于抗体阴性组(11.9%),P=0.000;移植肾功能延迟恢复的发生率(12.5%)与抗体阴性组(9.2%)比较,差异无显著性,P=0.102;供者特异性抗体阳性组受者发生急性排斥后,移植肾肌酐水平高于抗体阴性组或无急性排斥组.结论供者特异性抗体与肾移植术后急性排斥有关, 可能影响近期移植肾功能.
- [1]Sumitran-Holgersson S.HLA-specific alloantibodies and renal graft outcome.[J].2001,16(5).
- [2]Mauiyyedi S,Colvin RB.Humoral rejection in kidney transplantation: new concepts in diagnosis and treatment.[J].2002,11(6).
- [3]Tolkoff-Rubin N,Williams WW,Colvin RB,etc.Acute humoral rejection in renal allograft recipients: I. Incidence, serology and clinical characteristics.[J].2001,71(5).
- [4]Bian H,Reed EF,Harris PE.Ligation of HLA class I molecules on smooth muscle cells with anti-HLA antibodies induces tyrosine phosphorylation, fibroblast growth factor receptor expression and cell proliferation.[J].1998,10(9).
- [5]Poggi E,Piazza A,Servetti S,etc.Relevance of posttransplant HLA class I and class II antibodies on renal graft outcome.[J].2001,33(1).
- [6]McKenna RM,Takemoto SK,Terasaki PI.Anti-HLA antibodies after solid organ transplantation.[J].2000,69(3).