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Research progress on the role of cellular iron death in the treatment of inflammatory bowel disease

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Author:: No author available

Journal Title:: China Medicine

Issue:: 2

DOI:: 10.3760/j.issn.1673-4777.2023.02.035

Key Word:: 炎症性肠病;铁死亡;溃疡性结肠炎;克罗恩病

Abstract：炎症性肠病(IBD)是一类病因和发病机制尚未完全明确的炎症性疾病,努力探究IBD发病的机制和治疗靶点是炎症性肠病研究工作的重点.近年来,随着对IBD病理研究的不断深入,人们逐渐认识到IBD的病理过程中存在一种新型的细胞死亡形式,即铁死亡.研究发现,IBD患者病理组织中存在与铁死亡发生密切相关的一系列病理变化,本文对铁死亡及其在IBD病理中的作用和近年来有关通过铁死亡相关靶点对改善疾病的作用机制及表现进行综述,为铁死亡靶向治疗IBD的新思路提供研究依据.

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