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Research progress on potential targets of Streptococcus pneumoniae pneumonia

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Author:: No author available

Journal Title:: China Medicine

Issue:: 12

DOI:: 10.3760/j.issn.1673-4777.2022.12.031

Key Word:: 肺炎链球菌肺炎;代谢;免疫;靶点

Abstract：肺炎链球菌是常见的革兰阳性致病菌,可以引发多种感染性疾病,在儿童感染中致死率较高.肺炎链球菌肺炎严重威胁着人类健康,且全球抗菌药物耐药问题日益严重,提出更加高效治疗肺炎链球菌肺炎的方案,将有利于提高患者的生存率和减少患者的经济负担.肺炎链球菌溶血素是目前研究最深入的肺炎链球菌肺炎治疗靶点,但是研究者对其他靶点的整理尚不足.广泛研究肺炎链球菌肺炎的潜在靶点以备验证,增加干预疾病的方向并促进精准用药,能快速提高防治肺炎链球菌肺炎的效率.宿主和病原体是罹患肺炎链球菌肺炎的2个重要方面,现从肺炎链球菌肺炎的宿主和病原体2个角度对肺炎链球菌肺炎潜在靶点的作用进行综述,以期为寻找治疗肺炎链球菌肺炎的新靶点提供参考.

Reference

[1]刘早阳,任福强.天麻素抑制miR-223-3p对肺炎链球菌诱导的肺泡上皮细胞损伤的影响[J].2021,(6).
[2]王秋野,管仲莹.老年脑血管病患者合并肺部感染的病原学特点及耐药分析[J].2020,(10).
[3]熊玮,曾玉兰,杨荣时.老年吸入性肺炎病原学及临床分析[J].2016,(8).
[4]宋文良,刘春峰.儿童腺病毒肺炎免疫学特点及免疫学治疗方法[J].2019,(10).
[5]尤雷,翟俊伟,刘艳虹,等.非小细胞肺癌合并下呼吸道感染患者气道定植菌分布及危险因素分析[J].2022,35(3).
[6]刘艳芹,马香.肺炎链球菌性疾病的流行现状及预防研究进展[J].2020,(2).
[7]Marion C,Limoli DH,Bobulsky GS.Identification of a pneumococcal glycosidase that modifies O-linked glycans.[J].2009,77(4).
[8]Hartel T,Klein M,Koedel U,etc.Impact of glutamine transporters on pneumococcal fitness under infection-related conditions.[J].2011,79(1).
[9]Kristina Bram Knudsen,Christian Kofoed,Roall Espersen,etc.Visualization of Nanofibrillar Cellulose in Biological Tissues Using a Biotinylated Carbohydrate Binding Module of β-1,4-Glycanase[J].2015,28(8).
[10]Izquierdo-Garcia José Luis,Comella-del-Barrio Patricia,Campos-Olivas Ramón,etc.Discovery and validation of an NMR-based metabolomic profile in urine as TB biomarker[J].2020,10(1).
[11]Walkey, Allan J.,Quinton, Lee J.,Mizgerd, Joseph P..Integrative Physiology of Pneumonia[J].2018,98(3).
[12]Pouline M,van Oort,Paul,Brinkman,Gitte,Slingers,etc.Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study.[J].2019,316(5).
[13]刘俐嫔,王晓川.肺炎链球菌感染的免疫应答[J].2018,(9).
[14]Elizabeth M,Todd,Rashmi,Ramani,Taylor P,Szasz,etc.Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia.[J].2019,5(8).
[15]Gay K,Stephens DS.Structure and dissemination of a chromosomal insertion element encoding macrolide efflux in Streptococcus pneumoniae.[J].2001,184(1).
[16]Murphy MP,Evans GB,Furneaux RH,etc.The synthesis and antibacterial activity of totarol derivatives. Part 3: Modification of ring-B.[J].2000,8(7).
[17]Joanne K. Hobbs,Benjamin Pluvinage,Alisdair B. Boraston.Glycan‐metabolizing enzymes in microbe–host interactions: the Streptococcus pneumoniae paradigm[J].2018,592(23).
[18].Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study.[J].2017,5.
[19]Riley,L.M.,Weadge,J.T.,Baker,P.,etc.Structural and functional characterization of Pseudomonas aeruginosa AlgX: Role of algx in alginate acetylation[J].2013,288(31).
[20]Dalia AB,Standish AJ,Weiser JN.Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils.[J].2010,78(5).
[21]Hentrich, Karina,Lofling, Jonas,Pathak, Anuj,etc.Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR[J].2016,20(3).
[22]Hava DL,Camilli A.Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors.[J].2002,45(5).
[23]Mahajan, Sonal,Ramya, Thirumalai Nallan Chakravarthy.Cellulophaga algicola alginate lyase inhibits biofilm formation of a clinical Pseudomonas aeruginosa strain MCC 2081[J].2021,73(2).
[24]Walsh, Martin A.,Potter, Jane A.,Lukacik, Petra,etc.Streptococcus pneumoniae NanC STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR[J].2015,290(46).