Clinical significances of helper T cell 17, regulatory T cell and the expression of relative cytokines in psoriasis patients
- Author:
- No author available
- Journal Title:
- China Medicine
- Issue:
- 5
- DOI:
- 10.3760/j.issn.1673-4777.2018.05.032
- Key Word:
- 银屑病;辅助性T细胞17;调节性T细胞;白细胞介素;Psoriasis;Helper T cell 17;Regulatory T cell;Interleukin
Abstract： Objective To investigate the clinical significances of helper T cell 17(Th17),regulatory T cell (Treg) and the expression of relative cytokines in psoriasis patients.Methods From January to December in 2016,60 psoriasis patients(psoriasis group) and 30 healthy people(control group) were enrolled in 404 Hospital of the Chinese People's Liberation Army.Levels of Th17 and Treg were detected by flow cytometry;serum concentrations of interleukin(IL)-17 and IL-10 were detected by enzyme-linked immunosorbent assay.Results Th17 percentage in psoriasis group was higher than that in control group;Treg percentage in psoriasis group was lower than that in control group;Th17/Treg ratio in psoriasis group was higher than that in control group [(2.03 ± 0.27)％ vs (0.80 ±0.32)％,(1.10 ±0.21)％ vs (2.80 ±0.43)％,(1.91 ±0.46) vs (0.30 ±0.14)] (P ＜ 0.05).Serum IL-17 level in psoriasis group was higher than that in control group and serum IL-10 level in psoriasis group was lower than that in control group[(101 ± 11)ng/L vs (56 ±8)ng/L,(16 ±3) ng/L vs (30 ±6)ng/L] (P ＜ 0.05).Conclusion Psoriasis patients may have Th17 and Treg immune balance disorder.
- [1]程正位.溃疡性结肠炎患者B10细胞与ICOS阳性调节性T细胞的检测及临床意义[J].2015,(10).
- [2]蒋延伟,王忠永,邱会芬,等.Th17细胞和Treg细胞与银屑病关系的研究进展[J].2012,(3).
- [3]Li Jiawen,CHEN Xu'e,Liu Zhixiang,etc.Expression of Th17 Cytokines in Skin Lesions of Patients with Psoriasis[J].2007,(3).
- [4]王忠永,邱会芬,张建明,等.窄谱中波紫外线对寻常型银屑病患者外周血Th17/Treg失衡及相关细胞因子表达的影响[J].2014,(4).
- [5]何荣国,伍绍国,田华,等.寻常性银屑病患者外周血Th17/Treg失衡的研究[J].2011,(6).
- [6]Carrier YJ,Korn T,Bettelli E,etc.Reciprocal developmental pathways for the generation of pathogenic effector T(H)17 and regulatory T cells[J].2006,441(7090).
- [7]Sakaguchi N,Asano M,Sakaguchi S,etc.Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.[J].1995,155(3).
- [8]Sinclair SM,Allen KD,Jing L,etc.Interleukin-17 synergizes with IFNgamma or TNFalpha to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells.[J].2011,29(1).
- [9]Kagami S,Rizzo HL,Lee JJ,etc.Circulating Th17, Th22, and Th1 cells are increased in psoriasis.[J].2010,130(5).
- [10]Blander, JM,Torchinsky, MB.T helper 17 cells: discovery, function, and physiological trigger[J].2010,67(9).
- [11]赵辨.临床皮肤病学[M].2001.
- [12]Daniel, Mucida,Yunji, Park,Gisen, Kim,etc.Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.[J].2007,317(5835).
- [13]Dardalhon V,Korn T,Kuchroo VK,etc.Role of Th1 and Th17 cells in organ-specific autoimmunity.[J].2008,31(3).
- [14]Zhang L,Yang XQ,Cheng J,etc.Increased Th17 cells are accompanied by FoxP3(+) Treg cell accumulation and correlated with psoriasis disease severity.[J].2010,135(1).
- [15]Marc Veldhoen,Richard J. Hocking,Christopher J. Atkins,etc.TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells[J].2006,24(2).