Abstract： Objective To observe the effect of low-dose aspirin on serum uric acid level and renal function in patients with acute coronary syndrome (ACS).Methods Clinical records of 100 ACS patients admitted from January 2016 to June 2017 in Beijing Anzhen Hospital,Capital Medical University were reviewed;the patients were divided into observation group and control group (age and sex matched,n =50) according to different antiplatelet treatments;the observation group took aspirin enteric-coated tablets 100 mg/d and the control group took hydrogen clopidogrel sulfate 75 mg/d.Serum levels of uric acid and creatinine and glomerular filtration rate were analyzed before and 3,6 months after treatment.Results There were no significant differences of serum uric acid level,creatinine level and glomerular filtration rate between groups before treatment (P ＞ 0.05).Serum uric acid level 3,6 months after treatment in observation group were significantly higher than those before treatment [(376 ± 60),(378 ± 69) μmol/L vs (339 ± 40) μmol/L] and those in control group [(339 ± 45),(340 ± 49) μmol/L] (P ＜0.05).Serum creatinine level 6 months after treatment in observation group was significantly higher and glomerular filtration rate was significantly lower than those before treatment and those in control group [(88 ± 18) μmol/L vs (77±18),(78 ± 17) μmol/L;(77 ± 20) ml/(min · 1.73 m2) vs (92 ± 20),(90 ± 20) ml/(min · 1.73 m2)] (P ＜ 0.05).Conclusion Low-dose aspirin treating acute coronary syndrome may cause hyperuricemia and reduce glomerular filtration rate.