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丙泊酚对缺血性脑损伤的抗凋亡作用

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Author:: No author available

Journal Title:: China Medicine

Issue:: 11

DOI:: 10.3760/cma.j.issn.1673-4777.2015.11.042

Key Word:: 丙泊酚;缺血再灌注损伤;凋亡

Abstract：各种原因造成的局部组织器官的缺血,常常使细胞发生缺血性损伤,但在一定条件下恢复血液再灌注后,细胞的功能代谢障碍和结构损伤不但未减轻反而加重,这种现象称为缺血再灌注损伤(IRI).脑外伤、缺血性脑血管病和颅脑手术均会引起脑缺血,造成IRI,而细胞凋亡是整个损伤过程中的重要环节.有研究证明缺血性脑损伤后存在神经细胞凋亡[1],且细胞凋亡在迟发型神经损伤中占主导地位.

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