Abstract: Objective To explore the efficacy and safety of a combination of sodium ozagrel, aspirin and low molecular heparin calcium for patients with NSTEACS. Methods A total of 30 patients received aspirin and low molecular heparin calcium and 30 received aspirin and low molecular heparin plus sodium ozagrel. Results The therapeutic effect in sodium ozagrel group was significandy better than in control group (P<0.05). All blood clotting indexes and adverse reactions showed no significant difference between the two groups (P 0. 05). Conclusion The combination of aspirin and low molecular heparin calcium plus sodium ozagrel showes better outcome and safety for patients with NSTEACS.