Abstract： During the past three decades,the technology of implant surface modification has already formed well-developed methods including physical and chemical means.However,titanium is a kind of bioinert material,which will directly result in slowly bone-bond with bone tissue after implantation and ultimately reduce the success rate of dental implant surgery.Therefore,the introduction of bioactive substances which can effectively regulate and promote the proliferation of bone cells to modify the titanium implant surface has received tremendous attention in the research of oral implant field.The research of biological modification starts relatively late and it has not formed well-established system yet.The research progress is given in this paper concerning the bioactivators and methods used in biological modification.Furthermore,the current situation as well as the recent developments involving the biological modification of dental implant are also discussed in this review.