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Cytokeratin expression in cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma

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Author:: No author available

Journal Title:: Chinese Journal of Stomatology

Issue:: 11

DOI:: 10.3760/cma.j.issn.1002-0098.2014.11.004

Key Word:: 癌,鳞状细胞;牙龈肿瘤;颈淋巴结清扫术;肿瘤转移;Carcinoma,squamous cell;Gingival neoplasms;Neck dissection;Neoplasm metastasis

Abstract： Objective To examine the cytokeratin expression in cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma and its clinical significance.Methods The data of 42 cases with mandibular gingival squamous cell carcinoma after operation from July 2009 to December 2012 were included.Forty-two patients (male=27,formale=15) were included,with a mean age of 54.1 years (range 27-77).The lesions were staged(stage Ⅰ:9,stage Ⅱ:16,stage Ⅲ:6,stage Ⅳ:11).The cervical lymph nodes were examined by immunohistochemistry and HE.The cytokeratin expression in the lymph nodes was analyzed.Results The rates of lymph nodes metastasis detected by routine HE staining,serial sections HE staining and IHC were 8.0％(47/585),9.6％(56/585) and 12.8％ (75/585),respectively.There was significant difference (x2=7.17,P＜0.01) in the diagnosis of lymph nodes metastasis between IHC and routine HE staining,There was no significant difference between IHC and serial HE staining (x2=3.10,P＞0.05).Metastasis occurred mainly in the Level Ⅰ,Ⅱ and Ⅲ.Nineteen lymph nodes in 12 patients were found micrometastasis with IHC.Serial sections and routine HE staining did not find micrometastasis.Conclusions CK markers is sensitive in detecting lymph node metastasis of mandibular gingival squamous cell carcinoma.

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