Expression of transforming growth factor-β1 and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF STOMATOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1002-0098.2011.01.008
- Key Word:
- 癌,黏液表皮样;转化生长因子β1;抗原,核;Carcinoma,mucoepidermoid;Transforming growth factor betal;Antigens,nuclear
Abstract： Objective To investigate the expression and significance of transforming growth factor-β1 (TGF-β1)and Ki-67 nuclear antigen in salivary gland mucoepidermoid carcinoma. Methods The expression of TGF-β1 and Ki-67 nuclear antigen in 20 cases of salivary gland pleomorphic adenoma and 45 cases of mucoepidermoid carcinoma were detected by the streptavidin-peroxidase immunohistochemical method. Results Expression of TGF-β1 (39/45) and Ki-67 nuclear antigen (43/45) in mucoepidermoid carcinoma was significantly higher than in pleomorphic adenoma ( P ＜ 0.05 ). TGF-β1 expression was significantly higher in moderately/poorly differentiated mucoepidermoid carcinoma ( 16/16 ) than that in well differentiated mucoepidermoid carcinoma (23/29) and pleomorphic adenoma (12/20) ( P ＜ 0.05 ), but not different between well differentiated mucoepidermoid carcinoma (6/23) and pleomorphic adenoma (8/12)(P ＞ 0.05 ). The expression of Ki-67 was increased with the increment of TGF-β1 expression in mucoepidermoid carcinoma (P ＜ 0.05 ). Conclusions The high expression of TGF-β1 may play an important role in cell differentiation and malignant proliferation of mucoepidermoid carcinoma.
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